May you site have been hacked and you want to don’t allow execution of specific files with specific names.
May you have give upload access to a folder and you want in this folder php files cannot been executed.
You can do this with .htaccess file
Examples below
#With this htaccess snippet you can disallow all php files execution
<Files *.php>
deny from all
</Files>
#With this htaccess snippet you can disallow php files execution with name myphpfile.php
<Files *myphpfile.php>
deny from all
</Files>
#With this htaccess snippet you can disallow php files execution that exists in wp-content/uploads folder
<Files *wp-content/uploads/*.php>
deny from all
</Files>